Organ Transplantation Strategies for Primary Hyperoxaluria
Yifan Lu1, Tao Qiu1.
1Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China
Primary hyperoxaluria (PH) is a rare autosomal recessive disorder of glyoxylate metabolism. Persistent high concentrations of urinary oxalate leads to recurrent urinary stones, resulting in oxalate nephropathy, and in advanced stages of the disease, it can even cause multi-organ damage. Liver-kidney transplantation remains the important curative treatment for patients with PH. This article provides a concise overview of conventional management approaches and novel therapies for PH, with a particular focus on optimal transplantation strategies and postoperative management protocols in current clinical context.
[1] Primary hyperoxaluria
[2] Combined liver-kidney transplantation
[3] Kidney transplantation