Introduction: Early allograft dysfunction (EAD) is defined as a poor initial graft function after liver transplantation (LT). It is a serious complication that related with early post-LT morbidity and mortality. This study aimed to investigate the donor risk factors for EAD after living donor LT (LDLT).
Methods: Ninety-three patients who underwent LDLT between July 2015 and August 2024 were evaluated. EAD was classified by the presence of one or more of the following: total bilirubin ≥10mg/dL or international normalized ratio ≥1.6 on day 7, and alanine or aspartate aminotransferases >2000 IU/L within the first 7 days.
Results: EAD was developed in 20 (21.5%) patients. Patients who experienced EAD had inferior graft survival (p <0.01) and patient survival (p =0.03) survival to those who did not. EAD was the significant risk factor for both graft survival (p =0.021) and patient survival (p =0.027). Donor age (OR, 1.051; 95% CI, 1.008-1.096, p =0.020), and warm ischemic time (OR, 1.048; 95% CI, 1.001-1.098, p =0.046) were significant risk factors for development of EAD after LT (figure 1).

Conclusion: EAD negatively influenced on the graft and patient survival after LT. Donor age and intra-operative condition would be considered for its prevention in LDLT.