At the crossroads of end-of-life care and organ donation lies one of medicine’s most delicate and powerful moments - the chance to honor a patient’s final wishes while giving hope to others. This session invites you into a thoughtful and inspiring exploration of how healthcare professionals can navigate this intersection with compassion, clarity, and integrity. Panelists will discuss how the decision and practices around withdraw life-sustaining treatment can remain rooted in the patient's values and best interests while still allowing for deceased organ donation. Join distinguished voices from the US, Japan, Canada, and Spain as we discuss how to support families, protect ethical boundaries, and uphold dignity at every stage of care.